1,4-Dioxane hydrochloride → HCID 66989598, 화합물

HRID 2091549노트

반응식

HRID 2091549 반응식
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:44].O1CCOCC1>O1CCOCC1>[ClH:44].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11]

참가 물질

4

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 24798769HCID 24798769, 화합물

생성물 1

HCID 66989598HCID 66989598, 화합물수율 98%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

6-(4-t-Butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline (Reference Compound No. 4-1, 20.1 mg, 0.034 mmol) was dissolved in 1,4-dioxane (0.5 mL), 4N hydrogen chloride/1,4-dioxane solution (34 μL) was added thereto, and then the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to give the titled compound (17.5 mg) as a colorless solid. (Yield 98%)

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-56a0f8b577244de692e6a3137511bb93
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440660B2

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