HCID 178472436, 화합물 → HCID 178472435, 화합물
반응식
[ClH:1].[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]1.N[C@H]1CC[C@H](C(O)=O)CC1>>[ClH:1].[CH2:12]([O:11][C:9]([C@H:6]1[CH2:7][CH2:8][C@@H:3]([NH2:2])[CH2:4][CH2:5]1)=[O:10])[CH3:13]참가 물질
3
실험 절차
19.3 mL of concentrated hydrochloric acid (2.8 eq) was added to a solution of cis-4-aminocyclohexane carboxylic acid (10 g, 69.83 mmol) in anhydrous ethyl alcohol (250 mL). Mixture was stirred overnight at about 60° C. and then cooled to room temperature. Solvent was evaporated in vacuo. Crude material was then redissolved in acetonitrile, sonicated, and concentrated to a solid in vacuo. This acetonitrile wash was repeated three times to obtain 11.5 g of while solid (96% yield). Trans-ethyl 4-aminocyclohexanecarboxylate hydrochloride can be prepared following the same procedure using trans-4-aminocyclohexane carboxylic acid.
출처 및 근거
- ORD 기록
- ord-d2e5202ecf9e4ddb921b24a4e0b42e62
- 출처 데이터셋
- uspto-grants-2013_05