Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4,5-Trichloropyrimidine → (+/-)-cis-2-(2,5-Dichloropyrimidin-4-ylamino)cyclohexanecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | cis-2-Aminocyclohexanecarboxamide | HCID 2724813 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (+/-)-cis-2-(2,5-Dichloropyrimidin-4-ylamino)cyclohexanecarboxamide | HCID 86647791 | — |
반응 단계
A mixture of (±)-cis-2-aminocyclohexanecarboxamide (28 mg, 0.20 mmol), 2,4,5-trichloropyrimidine (37 mg, 0.20 mmol, 1 equiv.) and NaHCO3 (17 mg, 0.20 mmol, 1 equiv.) in a mixture of MeOH (1.0 mL) and H2O (0.5 mL) is stirred at room temperature for 12 h. The reaction is diluted with EtOAc and washed with water (2×), dried over Na2SO4 and concentrated in vacuo to generate the product (±)-cis-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexanecarboxamide; ESMS m/z 289.1 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08440681B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-6d11d90deffc4de2b63a04c1097f3c80 |
| 출처 메모 | uspto-grants-2013_05 |