Sodium Carbonate → HCID 59586793, 화합물

HRID 2091932노트

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HRID 2091932 반응식
Cl.[CH3:2][O:3][C:4]([C:6]1[N:7]([CH3:12])[CH:8]=[C:9]([NH2:11])[CH:10]=1)=[O:5].[Cl:13][C:14]1[N:19]=[C:18](Cl)[C:17]([Cl:21])=[CH:16][N:15]=1.C(=O)([O-])[O-].[Na+].[Na+]>CCO>[Cl:13][C:14]1[N:19]=[C:18]([NH:11][C:9]2[CH:10]=[C:6]([C:4]([O:3][CH3:2])=[O:5])[N:7]([CH3:12])[CH:8]=2)[C:17]([Cl:21])=[CH:16][N:15]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 2372592,4,5-TrichloropyrimidineHCID 2794656methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

생성물 1

HCID 59586793HCID 59586793, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
40 °C

실험 절차

The mixture of 4-amino-1-methyl-pyrrole-2-carboxylic acid methyl ester hydrochloride (95 mg, 0.5 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and sodium carbonate (106 mg, 1.0 mmol) in 3 mL of EtOH is heated at 40° C. overnight. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford methyl 4-(2,5-dichloropyrimidin-4-ylamino)-1-methyl-1H-pyrrole-2-carboxylate; ESMS m/z 301.0 (M+H+).

후처리

  1. filtrationThe precipitate is filtered
  2. washwashed by cold EtOH
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-cd5c05e8342249cda9704f3c46028513
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440681B2

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