Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Magnesium monoxide → 2-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Magnesium monoxide | HCID 6850729 | — |
| 반응물 | 1-Adamantyl carbamate | HCID 12437646 | — |
| 반응물 | 2-[2-(Carboxylatomethyl)-3-iodophenyl]acetate | HCID 21945688 | — |
| 촉매 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one | HCID 2807445 | 77% |
반응 단계
Tricyclo[3.3.1.13,7]dec-1-yl carbamate (100 mg, 0.512 mmol), iodobenzenediacetate (220 mg, 0.683 mmol), magnesium oxide (50 mg, 1.24 mmol) and rhodium (II) acetate dimer (22 mg, 0.050 mmol) were stirred in dichloromethane (3 mL) at 50° C. for 5 hours. After completion of the reaction, the reaction solution was filtered, and the solid was washed with chloroform and the filtrate was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1→2/1) to give the desired product (77% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08440666B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-d4ce184fdb4f48e6b71ded0bd1b8f1ab |
| 출처 메모 | uspto-grants-2013_05 |