Potassium Hydroxide → 2-Aminoadamantan-1-ol
반응식
[C:1]123[CH2:13][CH:8]4[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]4)[CH:5]1[NH:4]C(=O)[O:2]2)[CH2:11]3.[OH-].[K+]>O1CCOCC1>[NH2:4][CH:5]1[CH:6]2[CH2:7][CH:8]3[CH2:9][CH:10]([CH2:11][C:1]1([OH:2])[CH2:13]3)[CH2:12]2참가 물질
4
실험 절차
2-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one (76 mg, 0.395 mmol) in 1,4-dioxane (1 mL) was stirred with 5 M aqueous potassium hydroxide at 70° C. for 1 day. After completion of the reaction, the reaction solution was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to give the desired product (70% yield).
후처리
- customAfter completion of the reaction
- extractionthe reaction solution was extracted with chloroform
- dry with materialthe organic layer was dried over anhydrous sodium sulfate
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-16b0f917b0af4e0fb8be44be17ed4eba
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08440666B2
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