Potassium Hydroxide → 2-Aminoadamantan-1-ol

HRID 2092025

반응식

HRID 2092025 반응식
[C:1]123[CH2:13][CH:8]4[CH2:9][CH:10]([CH2:12][CH:6]([CH2:7]4)[CH:5]1[NH:4]C(=O)[O:2]2)[CH2:11]3.[OH-].[K+]>O1CCOCC1>[NH2:4][CH:5]1[CH:6]2[CH2:7][CH:8]3[CH2:9][CH:10]([CH2:11][C:1]1([OH:2])[CH2:13]3)[CH2:12]2

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 28074452-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one

생성물 1

HCID 124667122-Aminoadamantan-1-ol수율 70%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2-Oxa-4-azatetracyclo[6.3.1.16,10.01,5]tridecan-3-one (76 mg, 0.395 mmol) in 1,4-dioxane (1 mL) was stirred with 5 M aqueous potassium hydroxide at 70° C. for 1 day. After completion of the reaction, the reaction solution was extracted with chloroform, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to give the desired product (70% yield).

후처리

  1. customAfter completion of the reaction
  2. extractionthe reaction solution was extracted with chloroform
  3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-16b0f917b0af4e0fb8be44be17ed4eba
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440666B2

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