Trifluoroacetic acid → 1-Benzyl-1,2,3,4-tetrahydroquinolin-3-amine

HRID 2092170노트

반응식

HRID 2092170 반응식
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][CH:15]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:16]1)(C)(C)C.C(=O)([O-])[O-].[K+].[K+]>ClCCl.CO>[CH2:25]([N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:24][CH:15]([NH2:14])[CH2:16]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

6

반응물 3

HCID 6422Trifluoroacetic acidHCID 11430Potassium CarbonateHCID 67236612Tert-butyl 1-benzyl-1,2,3,4-tetrahydroquinolin-3-ylcarbamate

생성물 1

HCID 640312941-Benzyl-1,2,3,4-tetrahydroquinolin-3-amine

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (3 mL) was added to a solution of (1-benzyl-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid tert-butyl ester (481 mg, 1.42 mmol) in dichloromethane (6 mL), stirred for 30 minutes at ambient temperature, and concentrated. A solution of the resulting oil in methanol (10 mL) was treated with potassium carbonate (393 mg, 2.84 mmol), stirred for an hour at room temperature, and concentrated to afford the title compound as yellow residue. MS (DCI/NH3) m/z: 239.1 [M+H]+.

후처리

  1. concentrationconcentrated
  2. stirringstirred for an hour at room temperature
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b9b4f76b4c9f4a70ab9327bf1337f1c9
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440691B2

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