(S)-1-Hydrazino-butan-2-ol → (S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3-methoxy-5-trifluoromethyl-phenylamino)-[1,2,4]triazol-1-yl]butan-2-ol

HRID 2092219노트

반응식

HRID 2092219 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([NH:10][C:11](=[N:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([O:25][CH3:26])[CH:16]=2)SC)=O)[CH:5]=[C:4]([CH3:27])[N:3]=1.[NH:28]([CH2:30][C@@H:31]([OH:34])[CH2:32][CH3:33])[NH2:29]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[N:28]([CH2:30][C@@H:31]([OH:34])[CH2:32][CH3:33])[N:29]=[C:11]([NH:14][C:15]3[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([O:25][CH3:26])[CH:16]=3)[N:10]=2)[CH:5]=[C:4]([CH3:27])[N:3]=1

참가 물질

4

반응물 2

HCID 28082624(S)-1-Hydrazino-butan-2-olHCID 1361160191-(2-Chloro-6-methyl-pyridine-4-carbonyl)-3-(3-methoxy-5-trifluoromethyl-phenyl)-2-methyl-isothiourea

생성물 1

HCID 86644738(S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3-methoxy-5-trifluoromethyl-phenylamino)-[1,2,4]triazol-1-yl]butan-2-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of intermediate D6 (8.356 g, 0.020 mol) and intermediate D3 (2.083 g, 0.020 mol) in ethanol (200 ml) was stirred overnight at reflux. Subsequently, the solvent was evaporated to yield intermediate D7 (S-enantiomer) as a yellow oil that was used as such in the next reaction step.

후처리

  1. temperatureat reflux
  2. customSubsequently, the solvent was evaporated

출처 및 근거

ORD 기록
ord-cc7f36bb7fdf4c8aa52c4d36de27cd7f
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440701B2

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