4-Phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one → HCID 66818900, 화합물

HRID 2092358노트

반응식

HRID 2092358 반응식
[C:1]1([CH:7]2[C:16]3[C:11](=[C:12]4[CH:20]=[CH:19][CH:18]=[CH:17][C:13]4=[CH:14][CH:15]=3)[NH:10][C:9](=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S]>C(O)(=O)C>[C:1]1([C:7]2[C:16]3[C:11](=[C:12]4[CH:20]=[CH:19][CH:18]=[CH:17][C:13]4=[CH:14][CH:15]=3)[NH:10][C:9](=[O:21])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 28297134-Phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-oneHCID 5362487Sulfur2회

생성물 1

HCID 66818900HCID 66818900, 화합물수율 15%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
205 °C

실험 절차

A mixture of 4-Phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-one (0.55 g, 2.0 mmol) and sulfur (0.06 g, 2 mmol) was stirred at 205° C. for 0.5 hr under a nitrogen atmosphere. A second batch of sulfur (0.06 g, 2 mmol) was added and the solution stirred for 12 hr at 205° C. The product was dissolved in hot acetic acid and filtered. The clear filtrate upon cooling deposited crystals that were separated by filtration and washed with acetic acid and water followed by vacuum drying to afford the title compound (0.08 g, 0.30 mmol).

후처리

  1. stirringthe solution stirred for 12 hr at 205° C
  2. filtrationfiltered
  3. temperatureThe clear filtrate upon cooling
  4. customwere separated by filtration
  5. washwashed with acetic acid and water
  6. customdrying

출처 및 근거

ORD 기록
ord-35728be90a21446bb156cd7de36402ed
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440705B2

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