2-Thiophenemethanol → Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester thiophen-2-ylmethyl ester

HRID 2092362노트

반응식

HRID 2092362 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[OH:17][CH2:18][C:19]1[S:20][CH:21]=[CH:22][CH:23]=1>>[S:20]1[CH:21]=[CH:22][CH:23]=[C:19]1[CH2:18][O:17][C:10](=[O:11])[O:9][C@@H:3]1[CH:4]2[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]2)[CH2:2]1

참가 물질

3

반응물 2

HCID 694672-ThiophenemethanolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

생성물 1

HCID 59187160Carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester thiophen-2-ylmethyl ester

실험 절차

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with 2-hydroxy methyl thiophene.

출처 및 근거

ORD 기록
ord-a9e647b2cfa5434b9441f156e754a02c
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440690B2

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