Nitric Acid → N-(4-isopropyl-2-nitrophenyl)acetamide

HRID 2093038노트

반응식

HRID 2093038 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[N+:14]([O-])([OH:16])=[O:15].OS(O)(=O)=O>>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[C:6]([N+:14]([O-:16])=[O:15])[CH:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 258025N-[4-(Propan-2-yl)phenyl]ethanimidic acid

생성물 1

HCID 4200165N-(4-isopropyl-2-nitrophenyl)acetamide

실험 절차

N-(4-Isopropylphenyl)acetamide obtained in step I above was nitrated using nitric acid (1.2 eq)+H2SO4 (1.0 eq) at 0 to 5° C. for 2 hrs. After the completion of the reaction, reaction mixture was added to ice and pH was adjusted to 8, extracted with dichloromethane, which was evaporated to dryness to obtain N-(4-isopropyl-2-nitrophenyl)acetamide.

후처리

  1. customat 0 to 5° C.
  2. customfor 2 hrs
  3. customAfter the completion of the reaction, reaction mixture
  4. additionwas added to ice and pH
  5. extractionextracted with dichloromethane, which
  6. customwas evaporated to dryness

출처 및 근거

ORD 기록
ord-35811c0c89544a06825366812055ecfd
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440830B2

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