Water → 4-Isopropyl-2-nitroaniline
반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10]C(=O)C)=[C:6]([N+:14]([O-:16])=[O:15])[CH:5]=1)([CH3:3])[CH3:2].O.[OH-].[K+]>CO>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([N+:14]([O-:16])=[O:15])[CH:5]=1)([CH3:3])[CH3:2]참가 물질
5
실험 절차
To a solution of N-(4-isopropyl-2-nitrophenyl)acetamide obtained in step II above (1.0 eq) in MeOH and water was added KOH (1.5 eq) at room temperature and stirred for 5 hrs. Water was added to the reaction mixture and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the desired 4-isopropyl-2-nitroaniline. (Yield=65%).
후처리
- customthe organic layer was separated
- dry with materialdried over anhydrous Na2SO4
- concentrationconcentrated under reduced pressure
- customto afford crude product, which
- customon purification by column chromatography
출처 및 근거
- ORD 기록
- ord-4234ba66bd914b4fbc157bc7805b1ac9
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08440830B2
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