Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Amino-N,N-dimethyl-3-nitroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | N-[4-(dimethylamino)-2-nitrophenyl]acetamide | HCID 4396139 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Amino-N,N-dimethyl-3-nitroaniline | HCID 2733452 | 65% |
반응 단계
To a solution of N-[4-(dimethylamino)-2-nitrophenyl]acetamide obtained in step 11 above (1.0 eq) in MeOH and water was added KOH (1.5 eq) at room temperature and stirred for 5 hrs. Water was added to the reaction mixture and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the desired N-(4-amino-3-nitrophenyl)-N,N-dimethylamine. (Yield=65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08440830B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-c540b97dd5a64963ac6b323b56dcc6c9 |
| 출처 메모 | uspto-grants-2013_05 |