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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Dimethylformamide → methyl 2-({2-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl}carbamoyl)-N-phenyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carbimidothioate

HRID 2093068
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HRID 2093068 반응식
[CH3:1][S:2]/[C:3](=[N:16]\[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)/[N:4]1[CH2:9][CH2:8][C:7]2[N:10]=[C:11]([C:13]([OH:15])=O)[S:12][C:6]=2[CH2:5]1.[C:23]([O:27][C:28](=[O:39])[NH:29][C:30]1[CH:35]=[CH:34][C:33](OC)=[CH:32][C:31]=1[NH2:38])([CH3:26])([CH3:25])[CH3:24].CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1.CN([CH:64]=[O:65])C>C(N(CC)CC)C>[C:23]([O:27][C:28]([NH:29][C:30]1[CH:35]=[C:34]([O:65][CH3:64])[CH:33]=[CH:32][C:31]=1[NH:38][C:13]([C:11]1[S:12][C:6]2[CH2:5][N:4]([C:3]([S:2][CH3:1])=[N:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:9][CH2:8][C:7]=2[N:10]=1)=[O:15])=[O:39])([CH3:24])([CH3:25])[CH3:26]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 10752410tert-butyl N-(2-amino-4-methoxyphenyl)carbamateHCID 178503854HCID 178503854, 화합물

생성물 1

HCID 66864416
methyl 2-({2-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl}carbamoyl)-N-phenyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carbimidothioate

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A suspension of 5-[(Z)-(methylthio)(phenylimino)methyl]-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid obtained from step III of example 116 (1 eq), (2-amino-4-methoxy-phenyl)-carbamic acid tert-butyl ester (1.2 eq), EDCI (1.2 eq), HOBt (1.2 eq) and triethylamine in DMF were stirred at room temperature for 15 h. Solvent was evaporated and the residue was purified by either column chromatography or preparative HPLC to afford methyl 2-({2-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl}carbamoyl)-N-phenyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carbimidothioate.

후처리

  1. customSolvent was evaporated
  2. customthe residue was purified by either column chromatography or preparative HPLC

출처 및 근거

ORD 기록
ord-bb9aed13fd134e5cad1b9424dfda8e4a
출처 데이터셋
uspto-grants-2013_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08440830B2

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