Formaldehyde → tert-butyl 4,5-Dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
반응식
[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH2:9][C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].C=O.[CH3:18]C1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[S:12]1[C:11]2[CH2:18][N:7]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:15])[CH2:8][CH2:9][C:10]=2[CH:14]=[CH:13]1참가 물질
5
실험 절차
To a solution of tert-butyl[2-(3-thienyl)ethyl]carbamate in toluene was added paraformaldehyde (2 equi.) and catalytic amount of PTSA and reaction mixture was then refluxed in dean stark apparatus for 4 hrs. Reaction mass wan then concentrated and extracted with dichloromethane dried over sodium sulphate and evaporated to yield tert-butyl 4,7-dihydrothieno[2,3-c]pyridine-6(5H)— carboxylate.
후처리
- temperaturewas then refluxed in dean stark apparatus for 4 hrs
- customReaction mass
- concentrationwan then concentrated
- extractionextracted with dichloromethane
- dry with materialdried over sodium sulphate
- customevaporated
출처 및 근거
- ORD 기록
- ord-b043a35771784d9eb6582b7dc61ab5b2
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08440830B2
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