Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Oxalate → Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | 4-Methyl-3-nitropyridine | HCID 521828 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate | HCID 23269548 | — |
반응 단계
To a solution of freshly prepared sodium ethoxide was added diethyl oxalate (1.5 eq.) followed by 4-methyl-3-nitro pyridine (1 eq.) in toluene and reaction mixture was stirred overnight. It was then concentrated under reduced pressure and acidified with acetic acid to obtained red solid, which on further purification, by column chromatography provided the ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08440830B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-833d403d014e41518e19f7df95ba7f70 |
| 출처 메모 | uspto-grants-2013_05 |