Ethyl bromoacetate → Ethyl 2-(1,3-benzodioxol-5-ylamino)acetate
반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[O:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:17][CH2:18][O:19][C:20]([CH2:22]Br)=[O:21]>CN(C=O)C>[CH2:18]([O:19][C:20](=[O:21])[CH2:22][NH:10][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][O:3][C:4]=2[CH:9]=1)[CH3:17]참가 물질
5
실험 절차
To a solution of Benzo[1,3]dioxol-5-ylamine (1.2 eq.) and potassium carbonate (2.2 eq.) in DMF at 0° C. was added ethyl bromo acetate and stirred at room temperature for overnight. Reaction was then quenched with water and extracted with ethyl acetate, dried over sodium sulphate and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the (Benzo[1,3]dioxol-5-ylamino)-acetic acid ethyl ester.
후처리
- customReaction
- customwas then quenched with water
- extractionextracted with ethyl acetate
- dry with materialdried over sodium sulphate
- concentrationconcentrated under reduced pressure
- customto afford crude product, which
- customon purification by column chromatography
출처 및 근거
- ORD 기록
- ord-6c3822dff14744c8af4d2fbfc545ec6d
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08440830B2
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