Potassium Carbonate → HCID 67460186, 화합물

HRID 2093293노트

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HRID 2093293 반응식
Cl[C:2]1[C:7]([Cl:8])=[C:6]([C:9]([F:12])([F:11])[F:10])[N:5]=[C:4]([NH2:13])[N:3]=1.[CH3:14][C@H:15]1[CH2:23][C:22]2[C:17](=[CH:18][C:19]([CH3:24])=[CH:20][CH:21]=2)[C@@H:16]1[NH2:25].C(=O)([O-])[O-].[K+].[K+]>CC(N(C)C)=O>[Cl:8][C:7]1[C:2]([NH:25][C@H:16]2[C:17]3[C:22](=[CH:21][CH:20]=[C:19]([CH3:24])[CH:18]=3)[CH2:23][C@@H:15]2[CH3:14])=[N:3][C:4]([NH2:13])=[N:5][C:6]=1[C:9]([F:12])([F:11])[F:10]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 113222044,5-Dichloro-6-(trifluoromethyl)pyrimidin-2-amineHCID 67140611Trans-2,6-dimethylindan-1-amine

생성물 1

HCID 67460186HCID 67460186, 화합물수율 58%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

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온도
125 °C

실험 절차

A mixture of 0.10 g (0.43 mmol) of 4,5-dichloro-6-(trifluoromethyl)pyrimidin-2-amine, 0.08 g (0.51 mmol) of (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine and 0.14 g (1.3 mmol) of potassium carbonate in 1 ml of dimethylacetamide as solvent is heated at 125° C. for 30 minutes in a microwave appliance (Biotage Initiator, http://www.biotage.com/DynPage.aspx?id=22001). The crude mixture is absorbed on silica gel and, following column chromatographic separation, 0.089 g of 5-chloro-N4-[(1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-yl]-6-(trifluoromethyl)pyrimidin-2,4-diamine is obtained (solid, 55% yield, 95% purity).

후처리

  1. customThe crude mixture is absorbed on silica gel
  2. customcolumn chromatographic separation

출처 및 근거

ORD 기록
ord-0ea4108efb964630adbfc4efbe1c58c6
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445408B2

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