Water → HCID 59406814, 화합물

HRID 2093350

반응식

HRID 2093350 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:24][C:25]1[CH:33]=[CH:32][C:28]2=[N:29][S:30][N:31]=[C:27]2[CH:26]=1.O>CN(C=O)C>[N:29]1[S:30][N:31]=[C:27]2[CH:26]=[C:25]([CH2:24][N:14]3[C:13](=[O:16])[CH:12]=[CH:11][C:10]([C:4]4[CH:5]=[C:6]([F:9])[C:7]([F:8])=[C:2]([F:1])[CH:3]=4)=[N:15]3)[CH:33]=[CH:32][C:28]=12

참가 물질

6

반응물 4

HCID 962WaterHCID 10796Cesium carbonateHCID 5910045-(Bromomethyl)-2,1,3-benzothiadiazoleHCID 594068096-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one

생성물 1

HCID 59406814HCID 59406814, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3.0 g (13.3 mmol) of 6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one and 4.8 g (14.4 mmol) of caesium carbonate are suspended in 250 ml of DMF, 3.0 g (13.3 mmol) of 5-(bromomethyl)2,1,3-benzothiadiazole are added, and the mixture is stirred at room temperature. After 15 h, 110 ml of water are added to the reaction mixture, which is then stirred at room temperature for 2 h. The resultant precipitate is filtered off with suction and washed with water and dried in vacuo.

후처리

  1. stirringis then stirred at room temperature for 2 h
  2. filtrationThe resultant precipitate is filtered off with suction
  3. washwashed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-25b3a76f5f8b4313868866a40cd205f5
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445489B2

연결된 노트

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