Bosutinib → HCID 86610056, 화합물

HRID 2093370노트

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HRID 2093370 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH2:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]3)=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][C:13]=1[C:35]#[N:36]>C(O)(C)C.O>[CH:5]([O-:9])([CH3:6])[CH3:4].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH2:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]3)=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][C:13]=1[C:35]#[N:36]

참가 물질

3

반응물 1

HCID 5328940Bosutinib

생성물 1

HCID 86610056HCID 86610056, 화합물수율 162.3%

시약·촉매·용매 1

HCID 21889133Propan-2-ol--water (1/1)용매

실험 절차

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile (5 g) and 40 mL of a mixture of 2/1 isopropyl alcohol/water (v/v) were added to a 125 flask, and heated to reflux. The mixture was cooled over night to room temperature and filtered. The cake was washed with 15 mL of a 2/1 mixture of isopropyl alcohol/water (v/v) and vacuum dried at 45° C. to give 4.51 g of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monoisopropyl alcoholate as determined by GLC and NMR and determined to be Form III by XRD scans.

후처리

  1. temperatureheated to reflux
  2. filtrationfiltered
  3. washThe cake was washed with 15 mL of a 2/1 mixture of isopropyl alcohol/water (v/v) and vacuum
  4. customdried at 45° C.

출처 및 근거

ORD 기록
ord-68e07f86ba5a40428b73f0f5343fa90a
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445496B2

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