4-Bromobenzyl bromide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 2093453노트

반응식

HRID 2093453 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH3:10][S:11]([O:13][Na])=[O:12]>C(O)C>[CH3:10][S:11]([CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:13])=[O:12]

참가 물질

4

반응물 2

HCID 685274-Bromobenzyl bromideHCID 178504973HCID 178504973, 화합물

생성물 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

p-Bromobenzyl bromide (500 mg, 2 mmol) was refluxed with MeSO2Na (306 mg, 3 mmol) in Ethanol for 1 hour. The reaction was cooled, concentrated and purified by flash column (50% acetone/hexanes) to give the desired product.

후처리

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated
  3. custompurified by flash column (50% acetone/hexanes)

출처 및 근거

ORD 기록
ord-4e14562e96cb4dd0b49ba042177958d4
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445499B2

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