(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate → (R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

HRID 2093661

반응식

HRID 2093661 반응식
[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]2[CH2:20]CC[CH2:17]2)[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1>CC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]([CH3:20])[CH3:17])[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1

참가 물질

3

반응물 1

HCID 58405447(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate

생성물 1

HCID 59815009(R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Intermediate C-1 was prepared similarly to the synthetic methods used to prepare Intermediate A with the exception that acetone was used instead of cyclopentanone in the reductive amination step.

후처리

  1. customIntermediate C-1 was prepared similarly to the synthetic methods

출처 및 근거

ORD 기록
ord-70504879d261429a8348f1526e580ab1
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445503B2

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