Cesium carbonate → 5-chloro-N4-(5-methyl-1H-pyrazol-3-yl)-N2-(4-(piperidin-4-yl)naphthalene-1-yl)pyrimidine-2,4-diamine

반응식

Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:13]=[C:12]([CH3:14])[N:11](C3CCCCO3)[N:10]=2)[C:5]([Cl:21])=[CH:4][N:3]=1.C(OC([N:29]1[CH2:34][CH2:33][CH:32]([C:35]2[C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[C:38]([NH2:45])=[CH:37][CH:36]=2)[CH2:31][CH2:30]1)=O)(C)(C)C.C(=O)([O-])[O-].[Cs+].[Cs+]>C1COCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Cl:21][C:5]1[C:6]([NH:8][C:9]2[CH:13]=[C:12]([CH3:14])[NH:11][N:10]=2)=[N:7][C:2]([NH:45][C:38]2[C:39]3[C:44](=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:35]([CH:32]3[CH2:31][CH2:30][NH:29][CH2:34][CH2:33]3)=[CH:36][CH:37]=2)=[N:3][CH:4]=1