Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dipropylamine → 3-(Dipropylcarbamoyl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dipropylamine | HCID 8902 | — |
| 반응물 | Benzoic acid, 3-((dipropylamino)carbonyl)-, methyl ester | HCID 182776 | — |
| 반응물 | 3-(Methoxycarbonyl)benzoic acid | HCID 601880 | — |
| 반응물 | N-Boc-cis-4-hydroxy-D-proline | HCID 688616 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(Dipropylcarbamoyl)benzoic acid | HCID 182769 | — |
반응 단계
Step E (1): Methyl 3-(dipropylcarbamoyl)benzoate. To a solution of 3-(methoxycarbonyl)benzoic acid (6.7 g, 37.2 mmol) in DMF (60 mL) was added HATU (17.0 g, 44.7 mmol) and dipropylamine (9.4 g, 93 mmol) and the reaction mixture was stirred at rt overnight. Ethyl acetate (600 mL) was added and the mixture was washed with H2O, dried and concentrated to give the title compound was used in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745470B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-b9ee9195d30b401ea3470495f37b483c |
| 출처 메모 | uspto-grants-2010_06 |