Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid | HCID 66731908 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride | HCID 86069407 | — |
반응 단계
290 mg (1.02 mmol) 4-(2-carboxymethoxy-ethylamino)-3-nitro-benzoic acid in 100 ml dichloromethane are combined with 0.186 ml (2.55 mmol) thionyl chloride and 2 drops of DMF and refluxed for one day. After evaporation of the solution i. vac. it is evaporated with toluene and the residue is further reacted without any more purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08445525B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-cc7afd95aa38442e8bcc227179813f27 |
| 출처 메모 | uspto-grants-2013_05 |