Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-Chloro-4-(1,1-dioxo-[1,2]thiazinan-2-yl)-toluene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium tertbutoxide | HCID 50987170 | — |
| 반응물 | 2-chloro-N-(4-chlorobutyl-sulphonyl)-4-methyl-aniline | HCID 67048682 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Chloro-4-(1,1-dioxo-[1,2]thiazinan-2-yl)-toluene | HCID 66731721 | — |
반응 단계
1.27 g (4.29 mmol) 2-chloro-N-(4-chlorbutyl-sulphonyl)-4-methyl-aniline are stirred together with 722 mg (6.43 mmol) potassium-tert.-butoxide in 50 ml DMF for 16 hours at 60° C. Then the reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac. The residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08445525B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-4a2b9096f60248988f35e97002aefd5d |
| 출처 메모 | uspto-grants-2013_05 |