참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl trichloroacetate | HCID 10588 | — |
| 반응물 | 4-(4-Aminophenoxy)-N-methylpicolinamide | HCID 16655129 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-methyl-4-(4-(2,2,2-trichloroacetamido)phenoxy)picolinamide | HCID 68728447 | 87.6% |
반응 단계
4-(4-aminophenoxy)-N-methylpicolinamide (35 g, 0.144 mol) was mixed with ethyl-2,2,2-trichloroacetate (50 ml, 0.27 mol) in toluene (350 ml) at ambient temperature. The mixture was then heated to 100° C. under distillation mode for 2-3 hours. The organic solvent was degassed under reduced pressure to obtain oil. This oil was triturated with hexane (500 ml) to obtain (49 g) of the desired solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08445687B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_05 |
|---|
| ORD ID | ord-284905d4c53f4ad3bcd9f9c896f6b010 |
|---|
| 출처 메모 | uspto-grants-2013_05 |
|---|
