tert-Butyldimethylsilyl chloride → HCID 59524394, 화합물

HRID 2095079노트

반응식

HRID 2095079 반응식
Cl.[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C@@H:8]([C:13]([O:15][CH3:16])=[O:14])[NH:9][CH2:10]2)=[CH:5][CH:4]=1.[C:17]([Si:21](Cl)([CH3:23])[CH3:22])([CH3:20])([CH3:19])[CH3:18]>>[Si:21]([O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C@@H:8]([C:13]([O:15][CH3:16])=[O:14])[NH:9][CH2:10]2)=[CH:5][CH:4]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:23])[CH3:22]

참가 물질

3

반응물 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 66719276HCID 66719276, 화합물

생성물 1

HCID 59524394HCID 59524394, 화합물수율 87%

실험 절차

Prepared as in Example 12-1c from (S)-methyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (Example 13-1c) and tert-butylchlorodimethylsilane. Yield 87%, yellow oil. MS 322 (MH+).

출처 및 근거

ORD 기록
ord-f598cf0f7baa431785a58e021e56332e
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445692B2

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