Diethyl Ether → Ethyl 5-(morpholin-4-yl)pentanoate

HRID 2095185노트

반응식

HRID 2095185 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.C(N(CC)CC)C.C(OCC)C>C(O)C>[N:11]1([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 8083MorpholineHCID 8471TriethylamineHCID 84580Ethyl 5-bromovalerate

생성물 1

HCID 16097789Ethyl 5-(morpholin-4-yl)pentanoate수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 5-bromovalerate (8 g, 38.3 mmole), morpholine (3.67 g, 42 mmole) and triethylamine (4.2 g, 42 mmole) in ethanol (100 mL) was heated to reflux overnight. The solution was concentrated to afford a gummy white solid which was mixed with diethyl ether and filtered to remove the solid. The filtrate was washed with saline (3×50 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford 7.1 g (87%) of ethyl 5-morpholin-4-ylpentanoate as a pale brown liquid. MS (m/z, ES+): 217 (M+2, 100%), 216 (M+1, 57%).

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. concentrationThe solution was concentrated
  4. customto afford a gummy white solid which
  5. filtrationfiltered
  6. customto remove the solid
  7. washThe filtrate was washed with saline (3×50 mL)
  8. dry with materialdried over Na2SO4
  9. filtrationfiltered
  10. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4fc91f490fdc48c8a26d373c6d7a98eb
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445694B2

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