Borane;tetrahydrofuran → ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate
반응식
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:7]2[CH2:16][CH2:17][C:18](OCC)=[O:19].B.C1COCC1>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:7]2[CH2:16][CH2:17][CH2:18][OH:19]참가 물질
4
실험 절차
To a mixture of EXAMPLE 1A (1.85 g) in THF (50 mL) was added 1M borane•THF (30 mL). The mixture was stirred at room temperature for 16 hours, quenched with methanol (10 mL) and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5-25% ethyl acetate/hexanes.
후처리
- customquenched with methanol (10 mL)
- concentrationconcentrated
- customThe concentrate was purified by flash column chromatography on silica gel with 5-25% ethyl acetate/hexanes
출처 및 근거
- ORD 기록
- ord-14134b3480c24089af02995c773fc263
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08445679B2
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