2,6-Dichlorobenzaldehyde → (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2,6-dichlorophenyl)methanol

HRID 2095612노트

반응식

HRID 2095612 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:11]([C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15](F)[C:14]=3[Cl:21])[OH:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.ClC1C=CC=C(Cl)C=1C=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:11]([C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:21])[OH:12])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 67372,6-DichlorobenzaldehydeHCID 67004517(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,6-dichloro-3-fluorophenyl)methanol

생성물 1

HCID 67004341(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2,6-dichlorophenyl)methanol

실험 절차

Prepared according to the method described above for synthesis of (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2,6-dichloro-3-fluorophenyl)methanol, using 2,6-dichloro-benzaldehyde. MS (ES+): m/z 370.85, 372.85, 374.83 [MH+]; HPLC: tR=3.25 min (ZQ3, polar—5 min).

후처리

  1. customPrepared
  2. custom5 min

출처 및 근거

ORD 기록
ord-39d094ce2757424eb2f2243d1c51b7ca
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445510B2

반응 노트

불러오는 중…