Acetic Acid → N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide acetate

HRID 2095962노트

반응식

HRID 2095962 반응식
[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:21]=[CH:20][C:19]([NH:22][C:23]([C:25]5[C:26](=[O:39])[N:27]([C:32]6[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=6)[C:28]([CH3:31])=[CH:29][CH:30]=5)=[O:24])=[CH:18][C:17]=4[F:40])=[CH:11][N:10]3[CH:41]=2)=[O:5])[CH2:3][CH2:2]1.[C:42]([OH:45])(=[O:44])[CH3:43].CC(CC)=O>O>[C:42]([OH:45])(=[O:44])[CH3:43].[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:21]=[CH:20][C:19]([NH:22][C:23]([C:25]5[C:26](=[O:39])[N:27]([C:32]6[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=6)[C:28]([CH3:31])=[CH:29][CH:30]=5)=[O:24])=[CH:18][C:17]=4[F:40])=[CH:11][N:10]3[CH:41]=2)=[O:5])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 6569Methyl Ethyl KetoneHCID 44462744N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

생성물 1

HCID 66968889N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide acetate수율 66%

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

To N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide (700 mg, 1.26 mmol) was added acetic acid (3.5 mL), and the mixture was heated to 60° C. Methylethylketone (2.1 mL) and water (3.5 mL) were added, and the mixture was cooled to room temperature and stirred at room temperature for 16 hr. The precipitate was collected by filtration and washed with water to give the title compound (512 mg, 66%) as white crystals.

후처리

  1. temperaturethe mixture was cooled to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-3a5e1ff48ad64903ab5d7c3ab984736d
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445509B2

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