4-Hydroxy-4-(thiazol-5-yl)cyclohexanone → HCID 46241222, 화합물

반응식

[OH:1][C:2]1([C:9]2[S:13][CH:12]=[N:11][CH:10]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:14]1[CH2:17][CH:16]([NH:18][C:19]([CH2:21][NH:22][C:23](=[O:35])[C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=2)=[O:20])[CH2:15]1>>[F:30][C:28]1[CH:29]=[C:24]([CH:25]=[C:26]([C:31]([F:34])([F:32])[F:33])[CH:27]=1)[C:23]([NH:22][CH2:21][C:19](=[O:20])[NH:18][CH:16]1[CH2:17][N:14]([CH:5]2[CH2:6][CH2:7][C:2]([OH:1])([C:9]3[S:13][CH:12]=[N:11][CH:10]=3)[CH2:3][CH2:4]2)[CH2:15]1)=[O:35]

참가 물질

반응물 2

HCID 590174394-Hydroxy-4-(thiazol-5-yl)cyclohexanone

HCID 59361623HCID 59361623, 화합물

생성물 1

HCID 46241222HCID 46241222, 화합물

실험 절차

The title compounds were prepared as white solids from reductive amination of 4-hydroxy-4-thiazol-5-yl-cyclohexanone, as prepared in Example 40 Step B, and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-5-fluoro-benzamide using the procedure described in Step E of Example 1.

출처 및 근거

ORD 기록: ord-5b7dee66400849198ba89814e62b9277
출처 데이터셋: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08450304B2

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