Methanol → HCID 58424504, 화합물

HRID 2096515노트

반응식

HRID 2096515 반응식
Cl.[CH3:2][NH:3][OH:4].CO[Na].[Br:8][C:9]1[CH:10]=[C:11]2C(=[CH:17][CH:18]=1)O[CH2:14][CH2:13][C:12]2=[N:19][C:20]#[N:21].[CH3:22][OH:23]>>[Br:8][C:9]1[CH:10]=[C:11]2[C:12]3([O:4][N:3]([CH3:2])[C:20]([NH2:21])=[N:19]3)[CH2:13][CH2:14][O:23][C:22]2=[CH:17][CH:18]=1

참가 물질

5

반응물 4

HCID 887MethanolHCID 77906N-methylhydroxylamine hydrochlorideHCID 58424110N-(6-bromochroman-4-ylidene)cyanamideHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 58424504HCID 58424504, 화합물수율 88%

실험 절차

To a solution of N-methyl-hydroxylamine hydrochloride (101 mg, 1.2 mmol) in MeOH (4 mL) was added MeONa (0.24 mL, 25% (Wt.) in MeOH), followed by N-(6-bromochroman-4-ylidene)cyanamide (300 mg, 1.2 mmol). After stirring for 10 minutes, the solvent was removed in vacuo. The resulting residue was purified by preparative TLC to give 6-bromo-2′-methyl-2′H-spiro[chroman-4,5′-[1,2,4]oxadiazol]-3′-amine (315 mg, 88%).

후처리

  1. customthe solvent was removed in vacuo
  2. customThe resulting residue was purified by preparative TLC

출처 및 근거

ORD 기록
ord-40714242ca45453d8a0210cda8b2bd2d
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450308B2

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