반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][Br:10])[N:4]=1.[O:11]1[CH2:15][CH2:14][CH:13]([CH2:16][OH:17])[CH2:12]1>>[Br:10][CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:2][O:17][CH2:16][CH:13]2[CH2:14][CH2:15][O:11][CH2:12]2)[N:4]=1참가 물질
3
실험 절차
Prepared from 2,6-bis(bromomethyl)pyridine and (RS)-tetrahydrofuran-3-methanol by the alkylation method described for the final step of Example 32 to give the title compound (37%); NMR δH (400 MHz, CDCl3) 7.70 (1H, t, J 8.0 Hz), 7.37-7.33 (2H, m), 4.63 (2H, s), 4.53 (2H, s), 3.89-3.82 (2H, m), 3.77-3.72 (1H, m), 3.65-3.61 (1H, m), 3.56-3.46 (1H, m), 2.66-2.56 (1H, m), 2.09-1.99 (1H, m), 1.69-1.60 (1H, m); (M+H)+ 286, 288.
출처 및 근거
- ORD 기록
- ord-39873fd01f144913b2de41eb7562cb5e
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450328B2
연결된 노트
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