HCID 57539221, 화합물 → HCID 57539232, 화합물
반응식
C([N:8](CC1C=CC=CC=1)[C@H:9]([CH2:20][O:21][CH:22]([F:24])[F:23])[C:10]([O:12]CC1C=CC=CC=1)=[O:11])C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[NH2:8][C@H:9]([CH2:20][O:21][CH:22]([F:24])[F:23])[C:10]([OH:12])=[O:11]참가 물질
4
실험 절차
Benzyl (2R) 2-dibenzylamino-3-difluoromethoxy-propionate (3.1 g, 6.28 mmol) was stirred with Pd(OH)2 in methanol under H2 overnight. The reaction mixture was filtered and the filtrate concentrated to dryness, then triturated with diethyl ether to give (2R)-2-amino-3-(difluoromethoxy)propanoic acid (773 mg, 68.4%) as a white solid. 1H NMR (300 MHz, MeOD): (ppm) 6.49 (wt, 1H), 4.33 (dd, 1H), 4.22 (dd, 1H), and 3.88 (dd, 1H).
후처리
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated to dryness
- customtriturated with diethyl ether
출처 및 근거
- ORD 기록
- ord-3168f2e0bd8d46a2bc121e5ab54dcde6
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450336B2
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