Sulfuric Acid → 2-Fluoro-3-iodobenzoic acid
반응식
[F:1][C:2]1[C:9]([I:10])=[CH:8][CH:7]=[CH:6]C=1C#N.S(=O)(=O)(O)[OH:12].[O:16]1[CH2:21][CH2:20]OCC1>>[F:1][C:2]1[C:9]([I:10])=[CH:8][CH:7]=[CH:6][C:20]=1[C:21]([OH:16])=[O:12]참가 물질
4
반응 조건
- 온도
- 115 °C
실험 절차
A mixture of 2-fluoro-3-iodobenzonitrile (preparation 22a, 5.00 g, 20.2 mmol), dioxane (16 mL) and sulphuric acid (25 mL) was heated to 115° C. After 4 hours, the mixture was cooled and filtered. Water was added to the filtrate and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and evaporated to give the title compound (4.42 g, 82%) as a solid.
후처리
- temperaturethe mixture was cooled
- filtrationfiltered
- additionWater was added to the filtrate
- extractionthe mixture was extracted with ethyl acetate
- dry with materialThe organic layer was dried (MgSO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-aa40a567225948ffbedee37bd3881c95
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450341B2
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