2-Fluoro-3-iodobenzyl alcohol → 2-Fluoro-3-iodobenzaldehyde
반응식
[F:1][C:2]1[C:7]([I:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>ClCCl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[C:7]([I:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
Manganese (IV) oxide (15.40 g, 177 mmol) was added portionwise to a stirred solution of (2-fluoro-3-iodophenyl)methanol (preparation 22c, 4.03 g, 16 mmol) in dichloromethane (140 mL) and the mixture was stirred at 50° C. After 3 hours, the mixture was filtered through Celite® and the solvent was evaporated to give the title compound (2.10 g, 53%) as a white solid.
후처리
- filtrationthe mixture was filtered through Celite®
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-1d74945dfe634e5d9ed8810de5f2c9fc
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450341B2
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