HCID 12979373, 화합물 → 3,7-Dimethyl-1H-indole-2-carbaldehyde
반응식
[CH3:1][C:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH2:12][OH:13]>ClCCl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH:12]=[O:13]참가 물질
4
실험 절차
A mixture of (3,7-dimethyl-1H-indol-2-yl)methanol (440 mg, 2.5 mmol) and manganese dioxide (1.09 g, 12.5 mmol) in dichloromethane (15 mL) was stirred overnight at rt. The mixture was filtered and evaporated. The crude was chromatographed over silica gel eluting with ethyl acetate/hexane (5% and 7.5%) to afford the title compound (200 mg, 46%). 1H NMR (400 MHz, CDCl3) δ 10.00 (s, 1H), 8.75 (s, 1H), 7.51 (d, J=7.2 Hz, 1H), 7.15 (d, J=7.4 Hz, 1H), 7.05 (t, J=7.3 Hz, 1H), 2.61 (s, 3H), 2.45 (s, 3H).
후처리
- filtrationThe mixture was filtered
- customevaporated
- customThe crude was chromatographed over silica gel eluting with ethyl acetate/hexane (5% and 7.5%)
출처 및 근거
- ORD 기록
- ord-8500ad7e75ef4b818eb62592944e0787
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450307B2
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