(7-ethyl-3-methyl-1H-indol-2-yl)methanol → 7-ethyl-3-methyl-1H-indole-2-carbaldehyde

HRID 2097194노트

반응식

HRID 2097194 반응식
[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9]([CH2:12][OH:13])=[C:8]2[CH3:14])[CH3:2]>ClCCl.[O-2].[Mn+4].[O-2]>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9]([CH:12]=[O:13])=[C:8]2[CH3:14])[CH3:2]

참가 물질

4

반응물 1

HCID 59277628(7-ethyl-3-methyl-1H-indol-2-yl)methanol

생성물 1

HCID 592775647-ethyl-3-methyl-1H-indole-2-carbaldehyde수율 65%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (7-ethyl-3-methyl-1H-indol-2-yl)methanol (1.6 g, 9.1 mmol) and manganese (IV) oxide (3.97 g, 45.7 mmol) in dichloromethane (15 mL) was stirred overnight. The mixture was filtered through celite and evaporated to afford the title compound (1.1 mg, 65%). 1H NMR (400 MHz, CDCl3) δ 10.02 (s, 1H), 8.90 (s, 1H), 7.53 (d, J=8.0 Hz, 1H), 7.19 (d, J=7.6 Hz, 1H), 7.10 (t, J=7.7 Hz, 1H), 2.83 (q, J=7.5 Hz, 2H), 2.62 (s, 3H), 1.31 (t, J=7.5 Hz, 3H)

후처리

  1. filtrationThe mixture was filtered through celite
  2. customevaporated

출처 및 근거

ORD 기록
ord-2adf64cbce204a289a6622c7cc9aa31c
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450307B2

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