HCID 66602776, 화합물 → 2-(3-Cyclopropoxy-4-difluoromethoxyphenyl)-3-hydroxymethyl-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one
반응식
[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[N:24](COCC[Si](C)(C)C)[C:18]4[CH:19]=[N:20][NH:21][C:22](=[O:23])[C:17]=4[C:16]=3[CH2:33][OH:34])[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:14])[F:13])[CH2:3][CH2:2]1>O>[CH:1]1([O:4][C:5]2[CH:6]=[C:7]([C:15]3[NH:24][C:18]4[CH:19]=[N:20][NH:21][C:22](=[O:23])[C:17]=4[C:16]=3[CH2:33][OH:34])[CH:8]=[CH:9][C:10]=2[O:11][CH:12]([F:13])[F:14])[CH2:2][CH2:3]1참가 물질
3
실험 절차
Reaction was carried out in the same manner as in Example 1-(b) except for using 80 mg (0.16 mmol) of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-3-hydroxymethyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one obtained in Example 10-(b) in place of 2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one. After completion of the reaction, water was added to the reaction mixture and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried under reduced pressure to obtain 50 mg of the title compound as a white solid. (Yield: 85%)