3-Chloro-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one → 3-Cyclopropyl-2-(8-difluoromethoxy-2,2-dimethyl-2H-chromen-5-yl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one HCl
반응식
[CH:1]1([C:4]2[C:12]3[C:11](=[O:13])[N:10](COCC[Si](C)(C)C)[N:9]=[CH:8][C:7]=3[NH:6][C:5]=2[C:22]2[CH:31]=[CH:30][C:29]([O:32][CH:33]([F:35])[F:34])=[C:28]3[C:23]=2[CH:24]=[CH:25][C:26]([CH3:37])([CH3:36])[O:27]3)[CH2:3][CH2:2]1.[Cl:38]C1C2C(=O)NN=CC=2N(COCC[Si](C)(C)C)C=1C1C=CC(OC(F)F)=C(OC2CC2)C=1>>[ClH:38].[CH:1]1([C:4]2[C:12]3[C:11](=[O:13])[NH:10][N:9]=[CH:8][C:7]=3[NH:6][C:5]=2[C:22]2[CH:31]=[CH:30][C:29]([O:32][CH:33]([F:35])[F:34])=[C:28]3[C:23]=2[CH:24]=[CH:25][C:26]([CH3:37])([CH3:36])[O:27]3)[CH2:2][CH2:3]1참가 물질
3
반응물 2
생성물 1
실험 절차
Reaction was carried out in the same manner as in Example 6-(c) except for using 900 mg (1.70 mmol) of 3-cyclopropyl-2-(8-difluoromethoxy-2,2-dimethyl-2H-chromen-5-yl)-5-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo-[2,3-d]pyridazin-4-one obtained in Example 55-(b) in place of 3-chloro-2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]-pyridazin-4-one. After completion of the reaction, the solid obtained from the reaction suspension by filtration was washed with 1,4-dioxane and dried under reduced pressure to obtain 739 mg of the title compound as a white solid substantially quantitatively.