Aminopyrazine → HCID 66710701, 화합물

반응식

[N+](C1C=CC(O[C:11]([N:13]2[CH2:16][CH:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][N:19]=3)[CH2:14]2)=[O:12])=CC=1)([O-])=O.[NH2:25][C:26]1[CH:31]=[N:30][CH:29]=[CH:28][N:27]=1>>[N:27]1[CH:28]=[CH:29][N:30]=[CH:31][C:26]=1[NH:25][C:11]([N:13]1[CH2:14][CH:15]([O:17][C:18]2[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][N:19]=2)[CH2:16]1)=[O:12]

참가 물질

반응물 2

HCID 78747Aminopyrazine

HCID 580731193-(5-Bromo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

생성물 1

HCID 66710701HCID 66710701, 화합물수율 56.4%

실험 절차

This compound was prepared by the method outlined for example 5 step 4. Thus 3-(5-bromo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester (905 mg, 2.30 mmol) was reacted with 2-aminopyrazine (243 mg, 2.53 mmol) to afford the title compound (454 mg, 56%) as off white solid.

후처리

customThis compound was prepared by the method

출처 및 근거

ORD 기록: ord-8df45810ef754918ae5c55b949d583b0
출처 데이터셋: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08450346B2

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