Morpholine → HCID 178420764, 화합물

반응식

Cl[CH2:2][C:3]1[NH:7][N:6]=[N:5][N:4]=1.[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>>[NH:7]1[C:3]([CH2:2][N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:4][N:5]=[N:6]1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 178478452HCID 178478452, 화합물

생성물 1

HCID 178420764HCID 178420764, 화합물수율 82%

실험 절차

A solution of 5-(chloromethyl)-1H-tetrazole (260 mg, 2.2 mmol) in morpholine (1.5 mL, 17.2 mmol) was stirred at 25° C. for 20 minutes. The crude reaction mixture was purified by preparative LCMS using pH 2 buffer to yield the desired product (300 mg, 82%). MF═C6H11N5O; LCMS calculated for C6H12N5O(M+H)+: m/z=170.1.

후처리

customThe crude reaction mixture
customwas purified by preparative LCMS

출처 및 근거

ORD 기록: ord-4951add1ebc14f989dcca1f887f59613
출처 데이터셋: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08450351B2

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