2-(2-oxo-1,6-naphthyridin-1(2H)-yl)acetic acid → 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid
반응식
[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=[O:14]>CO.[Pd]>[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=[O:14]참가 물질
4
실험 절차
A suspension of 2-(2-oxo-1,6-naphthyridin-1(2H)-yl)acetic acid (150 mg, 0.734 mmol) and Pd/C (20 mg) in methanol was shaken under a 40 psi atmosphere of H2 for 18 h. The suspension was filtered through Celite and the filtrate was concentrated under vacuum to give 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetic acid. Retention time (min)=0.343, method [3], MS (ESI) 207.1 (M+H).
후처리
- filtrationThe suspension was filtered through Celite
- concentrationthe filtrate was concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-9e5ee51bed4d4ba0894a4a09eb9805b6
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450363B2
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