1,3-Dimethyluracil → Pyrazolo[1,5-a]pyriMidin-5(4H)-one
반응식
C[N:2]1[CH:9]=[CH:8][C:6](=[O:7])[N:5](C)[C:3]1=O.[O-]CC.[Na+].[NH:15]1[C:19](N)=[CH:18]C=N1>C(O)C>[N:15]1[N:2]2[CH:9]=[CH:8][C:6](=[O:7])[NH:5][C:3]2=[CH:18][CH:19]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
1,3-Dimethyl uracil (3.15 g, 22.5 mmol) and sodium ethoxide (23 mL of a 21% solution in ethanol) were added to a solution of 1H-pyrazol-5-amine (1.7 g, 20.4 mmol) in ethanol (50 mL). The resulting mixture was heated to 60° C. for 2 h and was then cooled to room temperature. The pale brown solid was isolated by filtration to give pyrazolo[1,5-a]pyrimidin-5(4H)-one (1.6 g, 58%). Retention time (min)=0.820, method [3], MS (ESI) 136.1 (M+H).
후처리
- temperaturewas then cooled to room temperature
- customThe pale brown solid was isolated by filtration
출처 및 근거
- ORD 기록
- ord-71e856259acd400dbfa3d0b493fdbe07
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450363B2
반응 노트
불러오는 중…