Dichloromethane → 2-(3,3-Difluoro-2-oxoindolin-1-yl)acetic acid

HRID 2098060노트

반응식

HRID 2098060 반응식
[F:1][C:2]1([F:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[C:3]1=[O:19].C(Cl)Cl>C(O)=O>[F:20][C:2]1([F:1])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([OH:14])=[O:13])[C:3]1=[O:19]

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 68754561tert-Butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate

생성물 1

HCID 687551942-(3,3-Difluoro-2-oxoindolin-1-yl)acetic acid

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A 30 mL reaction vial was charged with tert-butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate (275 mg, 1 mmol) as a yellow oil. DCM (3 mL) was added, followed by an equal volume of formic acid. The reaction was stirred for 16 h. The reaction mixture was concentrated under reduced pressure to give 2-(3,3-difluoro-2-oxoindolin-1-yl)acetic acid as a yellow solid. The desired M+H (228) was observed in the LCMS using the method [1] with a retention time of 1.652 min.

후처리

  1. customA 30 mL reaction
  2. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-dfe4c8fb30354f279678ef316dab8fb0
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450363B2

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