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Sodium Bicarbonate → HCID 86618406, 화합물

HRID 2098696
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HRID 2098696 반응식
Cl[C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=[O:12])=[CH:8][C:6]=2[N:7]=1.[NH:19]1[C:27]2[CH:26]=[CH:25][CH:24]=[C:23](B(O)O)[C:22]=2[CH:21]=[CH:20]1.C(=O)([O-])O.[Na+]>C1(C)C=CC=CC=1.C(O)C.O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[NH:19]1[C:27]2[C:22](=[C:23]([C:2]3[N:3]=[C:4]([N:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)[C:5]4[S:10][C:9]([CH:11]=[O:12])=[CH:8][C:6]=4[N:7]=3)[CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 3

HCID 516892Sodium BicarbonateHCID 27631731H-Indole-4-boronic acidHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

생성물 1

HCID 86618406HCID 86618406, 화합물수율 100%

시약·촉매·용매 4

HCID 178418476HCID 178418476, 화합물촉매
HCID 702
Ethanol
용매
HCID 962Water용매
HCID 1140Toluene용매

실험 절차

2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 (200 mg), 4-indole-boronic acid (125 mg), sodium hydrogen carbonate (178 mg) and PdCl2(PPh3)2 (4 mg) in toluene (1.5 ml), ethanol (0.75 ml) and water (0.4 ml) were heated in a microwave at 120° C. for 45 min. Chloroform/water extraction and purification on silica gave 2-(1H-indol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde (257 mg).

후처리

  1. extractionChloroform/water extraction and purification on silica

출처 및 근거

ORD 기록
ord-cc294f43eef0421e8731cfe8aac13a93
출처 데이터셋
uspto-grants-2013_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08450315B2

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