HCID 59590766, 화합물 → HCID 59590767, 화합물
반응식
C([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14]/[C:15]/2=[CH:18]\[C:19]([O:21][CH3:22])=[O:20])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14][CH:15]2[CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:11][CH:10]=1참가 물질
4
실험 절차
Under hydrogen, a mixture of (E)-methyl 2-(6-(benzyloxy)-2,3-dihydroinden-1-ylidene)acetate (1.3) (1.64 g, 5.57 mmol), palladium on carbon (10%) (0.462 g, 3.90 mmol) in MeOH (30 mL) were stirred for 24 hours. The mixture was then filtered through silica gel to remove the Pd—C, eluting with EtOAc. After removing solvent by rotary evaporation, the residue was purified using column chromatography (1:1 EtOAc/hexane). Product 1.4 was obtained in 68% yield as a colorless oil.
후처리
- filtrationThe mixture was then filtered through silica gel
- customto remove the Pd—C
- washeluting with EtOAc
- customAfter removing solvent
- customby rotary evaporation
- customthe residue was purified
출처 및 근거
- ORD 기록
- ord-ad60695382604aa0af26673dfed734bd
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450522B2
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