5-Cyclohex-1-enyl-3-phenylamino-thiophene-2-carboxylic acid methyl ester → HCID 178499262, 화합물

HRID 2099635

반응식

HRID 2099635 반응식
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]=2)=[CH:8][C:9]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4].[CH3:23][C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](Cl)=[O:31])[CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]=2)=[CH:8][C:9]=1[N:10]([C:30]([C@H:27]1[CH2:28][CH2:29][C@H:24]([CH3:23])[CH2:25][CH2:26]1)=[O:31])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4]

참가 물질

3

반응물 2

HCID 577953605-Cyclohex-1-enyl-3-phenylamino-thiophene-2-carboxylic acid methyl esterHCID 178461265HCID 178461265, 화합물

생성물 1

HCID 178499262HCID 178499262, 화합물수율 27%

실험 절차

The methyl ester from Step I (565 mg, 1.13 mmol) was acylated with trans-4-methylcyclohexyl carboxylic acid chloride as previously described (example 11, step II) to give 41 mg (27%) of 5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-phenyl-amino]-thiophene-2-carboxylic acid methyl ester.

출처 및 근거

ORD 기록
ord-fd826f308ef948e6a1cddb7bbafcf949
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569600B2

연결된 노트

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